Deplin (L-Methylfolate): Uses, Side Effects, and Dosage

Deplin (L-methylfolate) is a prescription medical food, sometimes referred to as a nutraceutical. It is formulated using folic acid, a form of vitamin B. Folic acid is the synthetic form of folate, a nutrient naturally occurring in our bodies and various foods, but may sometimes be deficient in individuals with major depressive disorder and schizophrenia.

Essential Information about Deplin

• Common side effects of Deplin may include agitation, anxiety, and gastrointestinal issues. Consult your healthcare provider if these effects occur and become bothersome.
• If you experience an allergic reaction to Deplin, call 911 or seek immediate medical attention.

How Deplin Works

Dietary folic acid requires "activation" or conversion to L-methylfolate to cross the blood-brain barrier. Deplin contains L-methylfolate, an already-active form of folic acid that doesn't require conversion. This makes it readily available for individuals who have trouble activating this nutrient.

Once in the brain, L-methylfolate undergoes a series of chemical reactions to reach its final form, which is crucial for synthesizing neurotransmitters like serotonin, dopamine, and norepinephrine. Balancing these neurotransmitters is essential for mood regulation, and imbalances can contribute to mental illness development.

Uses for Deplin

Folate deficiency has been associated with certain mental health disorders, including major depressive disorder and schizophrenia.

• Major Depressive Disorder: Research has found that low levels of folate can increase depression risk, and folate deficiency caused by poor diet can further aggravate depression symptoms.
• Schizophrenia: Low folate levels have been associated with an increased risk of schizophrenia. Folate aids in breaking down the amino acid homocysteine, and low folate levels can lead to high homocysteine levels, potentially causing neurodegeneration, a characteristic of schizophrenia.

Precautions and Contraindications

• Methylfolate supplements are generally safe during pregnancy. However, it's essential to inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding before taking Deplin. Dose adjustments may be necessary.
• Individuals with low vitamin B12 levels or red blood cell counts, or those who have had reactions to food, dyes, or preservatives, should inform their healthcare provider before using Deplin.

Dosage of Deplin

• Deplin is available in two dosages: 7.5 milligrams (mg) and 15 milligrams (mg). It is typically prescribed once daily.
• Your healthcare provider will determine the appropriate dosage based on your specific nutritional needs. Do not adjust the dosage without consulting your doctor.
• Generic formulations of Deplin include L-methylfolate calcium (Metafolin) and Algae-S powder (Schizochytrium).

How To Take and Store Deplin

• Deplin can be taken with or without food.
• Swallow the tablet whole without chewing or splitting.
• If you miss a dose, take it as soon as you remember. However, if it's close to the time for your next dose, skip the missed dose to avoid overdosing.
• Store Deplin in a dry place, at room temperature, and away from direct sunlight. Avoid humid or moist areas like bathrooms.
• Regular use of Deplin is essential for optimal benefits. Consult your doctor before discontinuing Deplin, and do not share it with others.

Emergency

If you suspect an overdose of Deplin, or if someone you know has overdosed, call your local poison control center or emergency room immediately, or call 911

Potential Side Effects of Deplin

• In studies, people taking L-methylfolate generally reported no more side effects than those taking a placebo.
• Some reported adverse effects include agitation, anxiety, and gastrointestinal issues.
• Discuss any bothersome side effects with your healthcare provider, who may adjust the dosage, discontinue Deplin, or switch you to a different medication.

Warnings and Interactions for Deplin

• Allergic reactions to Deplin are rare, but symptoms may include difficulty breathing, dizziness, skin rash, and swelling of the face, tongue, or throat. If any of these occur, stop taking Deplin and seek immediate medical attention.
• The potential interaction of Deplin with other medications has not been adequately studied. To be safe, inform your healthcare provider of all drugs, vitamins, or supplements you are taking before using Deplin.