Should You Take Vitamins for Depression?

If you suffer from chronic depression, a range of factors may be responsible for your symptoms. One potential cause is a deficiency in one or more essential nutrients. This could be good news, because along with medication, therapy, and other prescribed treatments, making simple dietary changes may help you feel better.

Keep in mind that the body benefits most from vitamins and minerals that come from whole foods rather than pills. In fact, even if you aren't low in any particular nutrient, eating a balanced diet in general—one made up of fresh foods rather than processed ones—can help you feel better overall.

At a Glance

• Many factors cause depression, but certain nutritional deficiencies may play a role.
• Vitamins for depression can include B1 (thiamine), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B12, B9 (folate), vitamin C, and vitamin D.
• Minerals that might affect depression include magnesium, calcium, selenium, zinc, iron, manganese, and potassium.

NOTE: Only a medical professional can determine if you have a nutritional deficiency, so before you fill your fridge with new foods or stock up on supplements, get an official diagnosis.

B-Complex Vitamins

B vitamins are essential for mental and emotional well-being. They're water-soluble, meaning they can't be stored in the body, so you need to get them through the foods you eat every day.

B vitamins may be depleted by alcohol, refined sugars, nicotine, and caffeine. Excesses of any of these can contribute to a B-vitamin deficiency.

Vitamin B1 (Thiamine)

The brain uses vitamin B1 to help convert glucose, or blood sugar, into fuel. Without it, the brain rapidly runs out of energy.

Thiamine deficiencies are rare but can lead to various disorders, including irritability and symptoms of depression. One study found that thiamine supplements might help counteract the time lag of antidepressants for people with major depressive disorder.

Natural food sources of vitamin B1 include:

• Acorn squash
• Asparagus
• Beans and legumes
• Beet greens
• Brussels sprouts
• Dairy products (e.g., yogurt)
• Eggs
• Meat, poultry, and fish
• Nuts and seeds
• Spinach
• Whole grains

If you're low in vitamin B1, you might want to avoid clams, milled rice, mussels, and shrimp. These foods contain the enzyme thiaminases, which renders thiamine inactive.

Vitamin B3 (Niacin)

A niacin deficiency can cause pellagra, a disease that can lead to psychosis and dementia. Since many commercial foods contain niacin, pellagra has virtually disappeared. However, deficiencies in vitamin B3 can produce agitation and anxiety, as well as mental and physical slowness.

Food sources of vitamin B3 include:

• Dairy products
• Eggs
• Fish
• Lean meats
• Legumes
• Nuts
• Poultry

Vitamin B5 (Pantothenic Acid)

Deficiencies of vitamin B5 are rare but may lead to fatigue, depression, insomnia, skin irritation, and numbness and tingling in the hands and feet.

Food sources of vitamin B5 include:

• Broccoli
• Chicken
• Cod
• Eggs
• Lentils
• Milk
• Whole-wheat bread
• Tuna
• Yogurt

Vitamin B6 (Pyridoxine)

Vitamin B6 helps the body process amino acids, which are the building blocks of proteins and some hormones. It is needed to make serotonin, melatonin, and dopamine. Many nutritionally oriented doctors believe that most diets do not provide optimal amounts of this vitamin.

Vitamin B6 deficiencies, although very rare, cause impaired immunity, skin lesions, and mental confusion. A marginal deficiency sometimes occurs in people with moderate to severe alcohol use disorder, people with kidney failure, and women using oral contraceptives.

Food sources of vitamin B6 include:

• Beef liver
• Chicken
• Chickpeas
• Cottage cheese
• Fish (e.g., tuna, salmon)
• Non-citrus fruits (e.g., bananas)
• Potatoes
• Squash

Vitamin B12

A vitamin B12 deficiency can lead to various neurologic and psychiatric symptoms. Because vitamin B12 is important for red blood cell formation, a deficiency can also cause anemia. Deficiencies take a long time to develop, since the body stores a three- to five-year supply in the liver.

When shortages do occur, they are often due to a lack of intrinsic factor: an enzyme that allows vitamin B12 to be absorbed in the intestinal tract.

This condition is known as pernicious anemia. Since intrinsic factor diminishes with age, older people are more prone to B12 deficiencies.

Food sources of vitamin B12 include:

• Chicken
• Eggs
• Fish (e.g., salmon, trout, white tuna)
• Meat
• Milk
• Yogurt

Vitamin B9 (Folate)

Vitamin B9 is needed for DNA synthesis. It is also necessary for the production of SAM (S-adenosyl methionine). A poor diet, illness, heavy alcohol use, and certain drugs can contribute to folate deficiencies.

Pregnant women are often advised to take this vitamin to prevent neural tube defects in the developing fetus.

Food sources of folate include:

• Asparagus
• Beans (e.g., chickpeas, black-eyed peas)
• Brussels sprouts
• Leafy green vegetables (e.g., spinach, kale, collards, endive)
• Peanuts
• Sunflower seeds

Vitamin C

When too little vitamin C plays a role in depression symptoms, supplements may help. While there are currently more animal than human studies showing the effects of vitamin C on depression, one small study of young male students linked higher levels with an improved overall mood and lower levels with increased depression, anger, and confusion.

Stress, pregnancy, and breastfeeding increase the body's need for vitamin C, while aspirin, tetracycline, and birth control pills can deplete the body's supply.

Food sources of vitamin C include:

• Broccoli
• Brussels sprouts
• Cauliflower
• Grapefruits
• Kiwi
• Melon
• Oranges
• Peppers
• Potatoes
• Strawberries
• Tomatoes

Vitamin D

Vitamin D is important to the body in many ways. Your body needs this key vitamin to absorb calcium. What's more, your bones need it to stay healthy and strong, your cells need it to grow, your nerves need it to carry messages between the brain and other body parts, and your immune system needs it to fend off viruses and bacteria.

The "sunshine vitamin" also plays a role in mental health.

More and more research has shed light on the link between a lack of vitamin D and depression.

One meta-analysis found that people with depression have low vitamin D levels and people with low vitamin D have a much greater risk of depression. While the best way to absorb vitamin D is through sun exposure, dietary supplements and certain foods are also viable sources.

Food sources of vitamin D include:

• Beef liver
• Cheese
• Egg yolks
• Fatty fish (e.g., salmon, tuna, mackerel)
• Fortified foods (e.g., milk, non-dairy milk, juice, yogurt, cereals)
• Mushrooms

Minerals

Deficiencies in a number of minerals have been associated with depressive symptoms as well as physical problems.

Magnesium

The fourth most abundant mineral in the human body, magnesium is mostly stored in your bones. While not common, magnesium deficiency can occur if you don't consume enough magnesium-rich foods.

Health problems, like diabetes and moderate to severe alcohol use disorder, as well as certain medication that interferes with the absorption of magnesium in your small intestine, can also cause a deficiency.

A deficiency of this essential mineral has been linked with personality changes, including apathy, depression, agitation, confusion, anxiety, and delirium.

Food sources of magnesium include:

• Dark green leafy vegetables
• Legumes
• Nuts and seeds
• Whole grains

Calcium

Calcium, which is the most abundant mineral in the body, is mostly stored in the bones and teeth, where it helps with formation and strength. It also plays a role in muscle contraction, normal nervous system function, blood clotting, and hormonal secretion.

Long-term calcium deficiency can lead to a loss of bone density (osteopenia) or brittle, weak bones (osteoporosis).

A diet low in calcium has also been shown to increase self-rated depression in middle-aged women.

Calcium deficiency can occur from a lack of calcium in your diet as well as an abundance of protein and sodium-rich foods, which are known to impair calcium absorption.

Food sources of calcium include:

• Cheese
• Fatty fish (e.g., salmon)
• Fortified foods (e.g., non-dairy milk, juice, cereals)
• Organic milk
• Yogurt

Selenium

Selenium is a trace mineral, meaning that your body only needs a small amount. Selenium is essential for normal thyroid function, reproduction, and DNA synthesis.

One study linked too high and too low levels of selenium in young people to an increased risk of symptoms of depression.

Selenium is often found in multivitamins as well as in the forms of selenomethionine, selenium-enriched yeast, or sodium selenite. It's still unknown how well the body absorbs selenium in supplement form.

Food sources of selenium include:

• Breads, cereals, and other grain products
• Dairy products
• Eggs
• Meat
• Poultry
• Seafood

Zinc

You need zinc for normal growth and a healthy immune system