Trazodone: Side Effects, Uses, and Overdose Information

What is Trazodone?

• Trazodone is an antidepressant used to treat major depressive disorder.
• It is approved by the FDA and available under the generic name trazodone hydrochloride.
• Brand names for trazodone include Desyrel, Desyrel Dividose, and Oleptro.

Off-Label Uses

• Trazodone may also be prescribed for conditions like generalized anxiety disorder, panic disorder, and insomnia, although these are off-label uses.

Common Side Effects

• Drowsiness or sedation
• Dizziness
• Constipation
• Blurred vision

Less Common Side Effects

• Appetite changes
• Diarrhea
• Dry mouth
• Muscle pain
• Nausea or vomiting
• Nervousness
• Nightmares
• Rash
• Sexual issues
• Stuffy nose
• Tired, itchy, or red eyes
• Shaking
• Weakness

Serious Side Effects (Seek Immediate Medical Attention)

• Unusual bleeding or bleeding that won't stop
• Irregular heartbeat
• Low blood pressure
• Low blood sodium
• Mania or hypomania
• Painful and prolonged erection of the penis (priapism)

Black Box Warning

• Trazodone carries a black box warning for increased risk of suicidal thinking or behavior in individuals under 24.
• If you experience suicidal thoughts, contact a healthcare provider or the National Suicide Prevention Lifeline (988).

Signs of Overdose

• Drowsiness
• Vomiting
• Painful erection
• Seizures
• Irregular heartbeat
• Difficulty breathing

Withdrawal Symptoms (When Discontinuing Trazodone)

• Anxiety
• Agitation
• Sleep disturbances

Important Information

• Use trazodone exactly as prescribed. Overdose is possible.
• Do not engage in potentially hazardous activities until you know how the drug affects you, especially driving.
• Do not discontinue trazodone without approval and guidance from your healthcare provider. A tapering schedule is usually recommended.

Consult a Healthcare Provider

• In case of serious side effects or signs of overdose, seek immediate medical attention.
• Discuss any side effects with your healthcare provider, especially if they persist or become bothersome.