Rexulti: Uses, Side Effects, and Dosages

About Rexulti

Rexulti (brexpiprazole) is an antipsychotic medication prescribed to treat mental health conditions such as depression and schizophrenia. Its mechanism of action involves balancing chemical neurotransmitters like dopamine and serotonin in the brain, aiming to improve symptoms and promote overall well-being.

Uses of Rexulti

• Major Depressive Disorder (MDD): Rexulti is used as an add-on treatment for individuals with MDD who do not respond adequately to antidepressant medications alone.

• Schizophrenia: Rexulti helps manage symptoms associated with schizophrenia, including hallucinations, delusions, and disorganized thinking.

Off-Label Uses of Rexulti

• Borderline Personality Disorder: Studies have suggested that Rexulti may be beneficial in improving mood instability and impulsive behaviors in individuals with borderline personality disorder.

• Bipolar Disorder: Rexulti has been used off-label to treat mood and thought symptoms associated with bipolar disorder.

Precautions Before Taking Rexulti

• Medical History Disclosure: Share your complete medical history with your doctor, including information about any ongoing medical conditions such as diabetes, seizures, blood pressure issues, or history of low white blood cell count.

• Allergy Information: It is crucial to inform your doctor about any allergies you may have, especially if you are allergic to brexpiprazole or any other ingredients present in Rexulti.

Precautions and Contraindications

• Brexpiprazole Allergy: Individuals with a known allergy to brexpiprazole should avoid taking Rexulti.

• Increased Body Temperature: Rexulti may elevate body temperature, potentially leading to dehydration, particularly in hot weather conditions. Stay hydrated and avoid overheating.

Rexulti Dosage

• MDD: The starting dosage for MDD is typically between 0.5 and 1 milligram once daily. Adjustments can be made to a maximum of 3 milligrams once daily, as needed.

• Schizophrenia: For schizophrenia, the initial dosage is usually 1 milligram once daily. Adjustments can be made up to a maximum of 4 milligrams once daily, based on individual needs.

How to Take and Store Rexulti

• Prescription Compliance: Follow the dosage and administration instructions provided by your doctor precisely.

• Avoid Discontinuation Without Consultation: Do not stop taking Rexulti without consulting your doctor, as abrupt discontinuation may cause symptoms to reoccur.

• Meal Considerations: Rexulti can be taken with or without food, as it does not affect its absorption.

• Storage Conditions: Store Rexulti in a cool, dry place at room temperature, away from moisture and direct sunlight.

• Handling and Administration: Handle Rexulti tablets with care, avoiding crushing, breaking, or chewing them. Ensure that you are using the correct dosage and follow the instructions provided by your healthcare provider.

Side Effects of Rexulti

Common Side Effects:

• Weight gain
• Headache
• Drowsiness
• Anxiety
• Constipation
• Fatigue
• Restlessness

Serious Side Effects:

• Increased risk of strokes in older adults with dementia
• Uncontrollable body movements
• Neuroleptic malignant syndrome (NMS)
• Elevated blood sugar levels
• Seizures
• Low white blood cell count

If you experience any of these severe side effects or have concerns regarding your health, consult your doctor immediately.

Warnings and Interactions

• Pediatric Use: The safety and effectiveness of Rexulti in individuals under 18 years of age have not been established. Therefore, its use is not recommended in this population.

• Dementia-Related Psychosis: There is an increased risk of death in elderly individuals with dementia-related psychosis who are prescribed Rexulti. Its use is generally not recommended in this population.

• Blood Sugar Monitoring: Individuals with diabetes or a family history of diabetes should monitor their blood sugar levels regularly, as Rexulti may elevate blood sugar levels.

• Antidepressant Concomitant Use: Using Rexulti in combination with antidepressants may increase the risk of suicidal thoughts or behaviors in children, teenagers, and young adults. Careful monitoring is necessary in such cases.

Conclusion

Rexulti is an antipsychotic medication primarily used to treat MDD and schizophrenia. Before starting Rexulti, a thorough discussion with your doctor is essential, especially if you have any underlying medical conditions or concerns. They can provide personalized advice regarding the suitability of Rexulti for your specific situation, potential benefits and risks, and any necessary precautions or monitoring.