Negative Side Effects of Antidepressants

Key Takeaways

• Antidepressants can cause unwanted effects called side effects.
• Dosage and medication adjustments may be necessary to manage side effects.
• Healthcare professionals can suggest coping strategies and monitor for severe reactions.
• Abruptly stopping antidepressants can lead to discontinuation syndrome.

Common Side Effects

• Anxiety
• Blurry vision
• Constipation
• Dizziness
• Dry mouth
• Fatigue
• Insomnia
• Nausea
• Numbness
• Weight gain
• Sexual side effects

Serious Side Effects

Serotonin Syndrome - Occurs when serotonin levels in the brain rise dangerously high. - Symptoms include: - Confusion - Agitation - Muscle twitching - Sweating - Shivering - Diarrhea - Fever - Seizures - Irregular heartbeat - Unconsciousness

Hyponatremia - Sodium levels in the blood drop dangerously low. - Symptoms include: - Confusion - Nausea - Headache - Loss of appetite - Muscle pain - Fatigue - Disorientation - Agitation - Psychosis - Seizures - Coma

Suicidal Thoughts - May occur, especially in people under 25. - Symptoms include: - Worsening of depression - Increased thoughts of suicide or death - Unusual changes in behavior

Allergic Reactions - Symptoms include: - Swelling - Itchy rash - Hives - Blisters - Difficulty breathing

Mania - May occur in people with bipolar disorder. - Symptoms include: - Increased energy and activity - Problems sleeping - Racing thoughts - Impulsive behavior - Extreme elevation of mood - Irritability - Pressured speech

Seizures - May occur, particularly with Wellbutrin (bupropion) and tricyclic antidepressants. - Symptoms include: - Uncontrollable jerking movements - Staring spells - Confusion - Abnormal sensations - Loss of consciousness

When to Seek Medical Help

• Call 911 for seizures that:

  • Last more than five minutes
  • Do not wake up afterward
  • Begin immediately afterward
  • Occur during pregnancy, injury, or diabetes
  • Occur in water
  • Are unusual compared to previous seizures

• Contact your doctor for:

  • Any worsening of depression or suicidal thoughts
  • Allergic reactions
  • Mania
  • Seizures
  • Hyponatremia

Discontinuation Syndrome

• Symptoms that may occur when stopping antidepressants too abruptly:
  • Agitation
  • Anxiety
  • Blurred vision
  • Electric shock sensations
  • Fatigue
  • Hallucinations
  • Insomnia
  • Irritability
  • Muscle pain
  • Sweating
  • Tingling
  • Upset stomach
  • Vivid dreams

Managing Side Effects

• Discuss coping strategies with your doctor.
• Gradually taper off antidepressants under your doctor's guidance.
• Avoid abrupt discontinuation to prevent discontinuation syndrome.

Remember:

• Never stop taking your antidepressant without consulting your doctor.