Lamictal: Uses, Side Effects, Dosages, Precautions

Key Points

• Lamictal is a medication used to treat bipolar disorder (maintenance treatment to reduce the occurrence of mood episodes) and control seizures.
• It is not recommended for individuals hypersensitive to Lamictal or those with a history of severe rash or hypersensitivity to other anticonvulsants.

Precautions

Before taking Lamictal, discuss any existing medical conditions, particularly liver or kidney problems, and any medications, supplements, or vitamins you are taking with your doctor.

Pregnancy, Breastfeeding, and Other Considerations

Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Dosage and Administration

• Start at a low dosage and gradually increase it over several weeks to avoid hypersensitivity reactions.
• Lamictal comes in various formulations: tablets, orally disintegrating tablets, and chewable dispersible tablets.
• Disperse Lamictal CD tablets in liquid, mix thoroughly, and take the entire mixture.
• Swallow Lamictal tablets whole with or without food. Lamictal CD can be swallowed whole, chewed, or diluted in liquid.
• Place Lamictal ODT on your tongue until dissolved; they can be taken with or without food.
• Do not double up on doses if you miss one; simply take the next dose as scheduled.

Side Effects

Common:

• Abdominal pain
• Back pain
• Dry mouth
• Fatigue
• Insomnia
• Nausea
• Sleepiness
• Stuffy or runny nose

Severe:

• Acute multi-organ failure
• Blood disorders like anemia
• Cardiac rhythm and conduction abnormalities
• Fever or enlarged lymph nodes (signs of hypersensitivity)
• Serious rash
• Suicidal behavior and ideation
• Worsening of bipolar symptoms or new symptoms

Warnings and Interactions

• Black box warning: Lamictal can cause a serious, potentially life-threatening hypersensitivity rash.
• Increased risk of blood and organ disorders, suicidal thoughts/behavior, and other hypersensitivity reactions.
• Avoid operating machinery if you experience dizziness or drowsiness.
• Consult your doctor before stopping Lamictal; abrupt discontinuation may cause withdrawal symptoms.

Additional Information

• Lamictal is available in generic form (lamotrigine).
• Other anticonvulsants used for bipolar disorder include Dilantin, Mysoline, phenobarbital, Tegretol, and Lamictal XR.