Fetzima: Uses, Side Effects, Dosages, Precautions

What is Fetzima?

Fetzima (levomilnacipran) is an antidepressant drug used to treat major depressive disorder (MDD) in adults. It is an extended-release capsule containing levomilnacipran, which belongs to a class of drugs known as selective serotonin and norepinephrine reuptake inhibitors (SNRIs). SNRIs work by blocking the reuptake of serotonin and norepinephrine, which are neurotransmitters involved in mood regulation.

Key Information

• Contraindications: Fetzima should not be taken by individuals with known allergies to levomilnacipran or milnacipran, narrow-angle glaucoma, or those who have taken an MAOI within the past 14 days.
• Age Restriction: Fetzima is not approved for use in children.
• Medical History Disclosure: Before starting Fetzima therapy, patients must inform their doctor about their medical history, current medications, and potential drug interactions.
• Possible Side Effects: Common side effects include nausea, vomiting, constipation, sweating, increased heart rate, erectile dysfunction, and heart palpitations.
• Impaired Performance: Fetzima can cause sleepiness or impair decision-making, thinking, and reaction time. Caution is advised when driving or operating heavy machinery until the effects of the medication are fully understood.
• Black Box Warning: Fetzima carries a black box warning, highlighting the increased risk of suicidal thoughts or actions in certain individuals during the early stages of treatment.
• Monitoring for Changes: Patients should monitor for sudden changes in mood, behavior, thoughts, or feelings, particularly during the early stages of treatment. Any such changes should be promptly reported to the doctor.
• Discontinuation: Abruptly stopping Fetzima without consulting a doctor may result in discontinuation syndrome or a return of depression.
• Medication Changes: Always consult your doctor before making any changes to your medication regimen, including dosage adjustments or discontinuation.

Uses of Fetzima

• Primary Use: Fetzima is primarily indicated for the treatment of MDD in adults.
• Additional Benefit: It may offer relief from fatigue, a common symptom associated with depression.

Considerations Before Taking Fetzima

• Comprehensive Evaluation: Your doctor will carefully assess your symptoms, medical history, current medications, and other relevant factors before prescribing Fetzima.
• Special Populations: If you have bipolar disorder, kidney problems, bleeding problems, difficulty urinating, alcohol use disorder, low sodium levels, or are pregnant or breastfeeding, it is crucial to discuss these conditions with your doctor.
• Suicidal Thoughts: If you are experiencing suicidal thoughts, it is essential to seek support from your doctor or a mental health professional.

Precautions

• Contraindications: Fetzima is contraindicated for individuals with allergies to levomilnacipran or milnacipran, narrow-angle glaucoma, or those who have recently taken an MAOI (within 14 days).
• Medication Interactions: Inform your doctor about all medications, supplements, and herbal products you are taking, as Fetzima may interact with MAOIs, antibiotics, antifungals, HIV medications, and certain medications for mood, anxiety, and pain.
• Alcohol Consumption: Avoid alcohol consumption while taking Fetzima, as it may increase the risk of side effects.

Dosage

• Starting Dose: Fetzima is typically initiated at a dose of 20 milligrams, which is gradually increased to 40 milligrams per day after two days.
• Recommended Range: The recommended dosage range for Fetzima is 40 to 120 milligrams daily, although the exact dosage will be determined by your doctor based on your individual needs and response to the medication.
• Administration: Take Fetzima consistently at the same time each day, with or without food. Swallow the capsule whole, do not crush or chew it.
• Missed Dose: If you miss a dose, take it as soon as you remember, unless it's close to the time for your next dose. Do not take double doses.
• Overdose: Seek immediate medical attention in case of an overdose.

Side Effects

• Common: Nausea, vomiting, constipation, sweating, increased heart rate, erectile dysfunction, and heart palpitations.
• Serious: High blood pressure, abnormal heart rate, abnormal bleeding, visual problems, difficulty urinating, mania, seizures, low sodium levels, suicidal thoughts or actions, serotonin syndrome, and severe allergic reactions.

Warnings and Interactions

• Pregnancy and Breastfeeding: Fetzima is not recommended during pregnancy or breastfeeding.
• Cognitive Impairment: Use caution when driving or operating machinery due to potential drowsiness or impaired cognitive function.
• Suicidal Thoughts Monitoring: Monitor for sudden changes in mood, behavior, thoughts, or feelings, especially during the early stages of treatment. Report any changes to your doctor promptly.
• Discontinuation Syndrome: Do not abruptly stop taking Fetzima without consulting your doctor, as this may lead to discontinuation syndrome or a return of depression.

Conclusion

Fetzima is a medication specifically designed to treat major depressive disorder (MDD) in adults. By increasing the levels of certain neurotransmitters in the brain, it helps alleviate symptoms of depression. However, it is important to have an open discussion with your doctor about your medical history, current medications, and any concerns you may have before starting Fetzima therapy. Be aware of potential side effects and drug interactions, and adhere strictly to the instructions provided by your doctor. If you experience severe side effects, seek immediate medical attention. Do not stop taking Fetzima without consulting your doctor.